Scientists have noted that children with narcolepsy-cataplexy have an increased prevalence of overweight/obesity.1-3 More recent studies have linked narcolepsy-cataplexy with precocious puberty, and have indicated that the earlier the onset of narcolepsy-cataplexy in a child, the greater the risk of precocious puberty.3 Weight loss can occur after treating narcolepsy-cataplexy in children, but the extent that treating narcolepsy-cataplexy can reverse precocious puberty has not been examined in depth.4 Exactly how narcolepsy and precocious puberty are related is unclear but research studies have produced some interesting findings.
During my site visiting years, I spent a considerable amount of time on planes reading accreditation applications. One thing that always puzzled me was that many centers included high and low ranges for sleep stages as a percentage of total sleep time. Despite the fact that my site visiting hit its peak in 2010, I think these numbers usually came from the 1974 opus by Williams, Karacan and Hirsch, which appears to be out of print. Patients with inadequate Stage 3 or excessive REM were branded as abnormal. But abnormal how?
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